It is prepared by extracting the female inflorescence of Humulus lupulus L., a Moraceae plant. It has the functions of anti-oxidation, antibacterial, and elimination of free radicals in the body. It can be used as a food additive to prevent food spoilage, and can be used as an antioxidant in medicine, cosmetics, health food and food. Therefore, hops have great development and utilization prospects. Hops is a perennial fibrous root entwined herb of dioecious Chemicalbook, which can grow in many parts of the world, mainly in the United States, Europe, Australia, South America and China.
Mainly contains resin, volatile oil, flavonoids, tannin and so on. Its active ingredients are contained in soft resin, mainly including Lupulone, Humulone, Isohumulone and Isovaleric acid. The volatile oil contains about 0.5%, which contains 10 kinds of components, mainly Myrcene, accounting for 30% to 50%, followed by humulene. Flavonoids include Astragalin, Isoquercitrin, Rutin, Kaempferitrin and other Chemicalbooks.
1. Antibacterial effect Hop extract, lupulone and humulone can inhibit the growth of Gram-positive bacteria in test tubes, such as Bacillus anthracis, Bacillus cereus, Diphtheria, Neisseria pneumoniae, Staphylococcus aureus, etc.; It has no inhibitory effect on Gram-negative bacteria, and can also inhibit Mycobacterium tuberculosis. The inhibitory effect on pathogenic and non-pathogenic fungi and actinomycetes is very weak or ineffective.
2. Sedative effect Hops extract can be sedative in small doses, hypnotic in medium doses, and paralyzed in large doses, and the sleep time caused by it starts slowly but lasts longer.
3. Estrogen-like effect Hops extract has strong estrogen-like effect. The estrogenic activity of hops mainly comes from the β-acid part of the resin, while the α-acid part has no such effect.
4. Antispasmodic effect Hops extract has a strong antispasmodic effect on the smooth muscle of rabbit jejunum, guinea pig duodenum and rat uterus, can resist smooth muscle spasm caused by choline and barium chloride, and has antihistamine effect.
5. Enhance respiratory function Hop infusion and volatile oil have mild and short-term antihypertensive effects on dogs (intravenous injection), but have no preventive and therapeutic effects on rat paw edema caused by carrageenan. Intravenous injection of lupulone can Enhance breathing function.
6. Antioxidant effect The antioxidant effect of hop water extract, the results show that the antioxidant effect of hop water extract is close to vitamin C, and has a dose-effect relationship, and the antioxidant substances of hops are thermally stable, so Chemicalbook shows that hops are A good natural antioxidant.
7. Estrogen-like effect The estrogen-like effect of hop extract is due to its competitive binding to estrogen receptors, inducing the activity of alkaline phospholipase, increasing the mRNA of progesterone receptors in cultured endometrial cells, and upregulating other An estrogen-inducible factor preselin-2.
8. The effect of anti-radiation on the effect of total flavonoids of hops on the number of leukocytes in irradiated mice was determined. The total flavonoids of hops had a protective effect on immune leukocytes in mice after irradiation, and the protective effect on leukocytes in the middle and high dose groups was higher than that in the ginkgo control group. Group.
9. Antiplatelet Activation Xanthohumol has potent antiplatelet activity, which inhibits platelet aggregation by inhibiting the formation of thromboxane.
10. Anti-obesity study investigated the anti-obesity effect of hops extract in male mice fed high-fat diet, high-fat diet plus 2% or 5% hop extract for 20 weeks. The results showed that hops extract could inhibit body weight and adipose tissue weight gain, adipocyte diameter, and high-fat diet-induced increase in hepatic lipids.
11. Other effects Hop extract can obviously inhibit the proliferation of cotton ball granulation tissue in rats, and also has a certain inhibitory effect on pleural hypertrophy caused by pleurisy in clinical practice.
ITEM | SPECIFICATION | TEST METHOD |
Active Ingredeints | ||
Xanthohumol | 3% 5% 10% 20% 98% | HPLC |
Physical Control | ||
Identification | Positive | TLC |
Odor | Characteristic | Organoleptic |
Taste | Characteristic | Organoleptic |
Sieve Analysis | 100% pass 80 mesh | 80 Mesh Screen |
Loss on Drying | 5% Max | 5g / 105C /5hrs |
Chemical Control | ||
Arsenic (As) | NMT 2ppm | USP |
Cadmium(Cd) | NMT 1ppm | USP |
Lead (Pb) | NMT 5ppm | USP |
Mercury(Hg) | NMT 0.5ppm | USP |
Solvent Residue | USP Standard | USP |
Microbiological Control | ||
Total Plate Count | 10,000cfu/g Max | USP |
Yeast & Mold | 1,000cfu/g Max | USP |
E.Coli | Negative | USP |
Salmonella | Negative | USP |
【Indications】 Clearing away heat and detoxifying, anti-tuberculosis, invigorating the stomach and digestion, soothing the nerves and diuretic, relieving cough and resolving phlegm. For bone steaming tuberculosis fever, indigestion, abdominal distension, insomnia, etc.