Shiitake mushroom polysaccharide (LNT) Shiitake mushroom polysaccharide is an active ingredient extracted from high quality Shiitake mushroom seeds, and is a host defense potentiator (HDP). Clinical and pharmacological studies have shown that shiitake mushroom polysaccharide has antiviral, antitumor, modulating immune function and stimulating interferon formation.
The active component of shiitake polysaccharide is β-(1-3)-D-glucan with branching, the main chain consists of β-(1-3)-linked The main chain consists of β-(1-3)-linked glucose groups, and along the main chain are randomly distributed by β-(1-6)-linked glucose groups in a comb-like structure.
Product Name | Shiitake mushroom extract |
Appearance | Brown yellow powder |
Active Ingredient | Polysaccharide |
Specification | 50% |
Test Method | UV |
Particle Size | 100% pass 80 mesh |
Storage | Cool dry place |
Shelf Life | 2 years |
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| Product Name: | Shiitake Mushroom Extract | Part Used: | Fruitbody |
| Latin Name: | Lentinus edodes | Extract Solvent: | Water&Ethanol |
| ITEM | SPECIFICATION | TESTING METHOD |
| Assay(Polysaccharides) | 30% Min. | CP2010-UV |
| Physical & Chemical Control | ||
| Appearance | Yellow-brown Fine Powder | Visual |
| Odor | Characteristic | Organoleptic |
| Tasted | Characteristic | Organoleptic |
| Sieve Analysis | 100% pass 80 mesh | 80mesh screen |
| Loss on Drying | 7% Max. | GB 5009.3 |
| Ash | 9% Max. | GB 5009.4 |
| As | 1.0ppm Max | GB 5009.11 |
| Pb | 2.0ppm Max | GB 5009.12 |
| Hg | 1.0ppm Max. | GB 5009.17 |
| Cd | 0.1ppm Max | GB 5009.15 |
| Microbiological | ||
| Total Plate Count | 10000cfu/g Max. | GB 4789.2 |
| Yeast & Mould | 100cfu/g Max | GB 4789.15 |
| E.Coli | Negative | GB 4789.3 |
| Staphylococcus | Negative | GB 29921 |
| Salmonella | Negative in 10 g | AOAC/Neogen Elisa |
| Yeast & Mold | 1000cfu/g Max | AOAC/Petrifilm |
| E.Coli | Negative in 1g | AOAC/Petrifilm |
| Staphlococcus Aureus | Negative | CP2015 |
Shiitake mushroom polysaccharide does not have immunopromoting effect on normal organisms, but it can enhance the immune response in tumor-bearing or infected organisms. Its preparation did not show direct anticancer effects in in vivo screening tests in animals, but significantly promoted the transforming effect of lymphocyte cultures in vitro. The antitumor activity of shiitake polysaccharide was once found to be weakened in thymectomized animals injected with anti-lymphocyte serum, and its effect was also weakened by the macrophage inhibitors keratin and silica gel. Therefore, mushroom polysaccharide is a specific immune adjuvant with thymus-dependent T-cell guidance and macrophage involvement. It recognizes antigenic macrophages in the spleen and liver, promotes the production of lymphocyte activating factors, releases various helper T-cell factors, and enhances the phagocytosis of host peritoneal macrophages. When the host organism is injected with mushroom polysaccharide for several hours, the levels of some physiologically active serum factors such as acute phase protein-inducing factor, vasodilator and hemorrhage-inducing factor, IL-1 production-inducing factor, IL3, and colony-stimulating The levels of some physiologically active factors such as acute phase protein inducers, vasodilator and hemorrhage inducers, IL-1 production inducers, IL3 and colony stimulating factors reached peak levels. The action of these factors on lymphocytes, hepatocytes, and vascular endothelial cells produces many effective immune responses, while leading to the tendency of precursor T cells in the thymus to mature, differentiate, proliferate, and release into the periphery
1.Application of shiitake mushroom polysaccharide in the field of medicine
As an immune adjuvant, mushroom polysaccharide is mainly used to inhibit the occurrence, development and metastasis of tumors, improve the sensitivity of tumors to chemotherapy drugs, improve the physical condition of patients and prolong their life span.
Combined with chemotherapeutic agents, mushroom polysaccharide has the effect of reducing toxicity and increasing effectiveness. The selectivity of chemotherapy drugs to kill tumor cells is poor, and they also have killing effect on normal cells, producing toxic side effects, resulting in chemotherapy not being carried out on schedule and in the right amount; due to the insufficient dose of chemotherapy, it often causes drug resistance of tumor cells, becoming refractory to cancer and affecting the efficacy. Taking mushroom polysaccharide during chemotherapy can enhance the efficacy of chemotherapy and reduce the toxic effects of chemotherapy; meanwhile, the incidence of white blood cell drop, gastrointestinal toxicity, liver function damage and vomiting of patients during chemotherapy are significantly reduced. This fully demonstrates that the use of mushroom polysaccharide with chemotherapy can increase the efficacy, reduce the toxicity, and enhance the immune function of the patient's body.
When combined with other drugs in the treatment of chronic hepatitis B, mushroom polysaccharide can improve the conversion of hepatitis B viral markers and reduce the side effects of antiviral drugs. In addition, mushroom polysaccharide can be used to treat Mycobacterium tuberculosis infection.
2. Application of polysaccharide in health food field
Shiitake mushroom polysaccharide is a special bioactive substance, a biological response enhancer and modulator, which can enhance humoral immunity and cellular immunity function. The mechanism of antiviral effect of shiitake mushroom polysaccharide may lie in its functions of improving the immunity of infected cells, enhancing the stability of cell membrane, inhibiting cellular lesions and promoting cell repair. Also, shiitake mushroom polysaccharide has anti-retroviral activity. Therefore, shiitake mushroom polysaccharide is an anti-influenza health food to be developed.