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Genistein

  • 98%
  • Off-White or Light Yellow Powder
  • BH
  • HPLC
  • 1KG
  • ISO/USDA Organic/EU Organic
  • Food Grade
  • 2 Years
  • Drum, Aluminum Foil Bag
  • Available
  • China
  • 5000 Kilograms/ Per Month
Availability:

What's genistein powder?

Genistein mainly exists in legumes, such as Sophora japonica and mountain bean roots. Genistein, namely genistein, is a rectangular or hexagonal rod-shaped crystal (60% ethanol) and dendritic crystal (ether), with a melting point of 297-298 ℃ (slightly decomposed). Soluble in DMSO and ethanol, almost insoluble in water. The solubility in water is 8.7 μ g / ml. changing the pH of the solution has no significant effect on genistein.

Genistein mainly exists in legumes, such as Sophora japonica and mountain bean roots. Genistein, namely genistein, is a rectangular or hexagonal rod-shaped crystal (60% ethanol) and dendritic crystal (ether), with a melting point of 297-298 ℃ (slightly decomposed). Soluble in DMSO and ethanol, almost insoluble in water. The solubility in water is 8.7 μ g / ml. changing the pH of the solution has no significant effect on genistein.

Genistein daidzein function

1. Inhibition of protein tyrosine kinases

Protein tyrosine kinases (PTKs) are important proteins that control cell growth and differentiation and play a key role in normal cell division and abnormal cell proliferation.

2. Inhibition of DNA topoisomerase II

Topoisomerase II (ToPoII) is involved in various nuclear processes such as DNA transcription and recombination, nuclear DNA replication, and chromosome segregation in the anaphase of mitosis.

3. Inhibition of matrix metalloproteinase activity and ornithine decarboxylase activity

4. Antioxidant effect

Genistein has three phenolic hydroxyl groups and has good antioxidant activity due to its high reactivity of hydroxyl substitution and its ability to phagocytose free radicals.

5. Inhibition of cell cycle

By inhibiting the activities of topoisomerase II and tyrosine protein kinase, Genistein induces the increase of P53 protein content in malignant cells, resulting in cell cycle arrest, thereby inhibiting the proliferation of malignant cells and promoting the programmed cell death of malignant cells.

6. Induction of apoptosis

7. Induction of Malignant Cell Differentiation

Genistein has a variety of cell differentiation-inducing effects, which can reverse cancer cells to normal cells or near-normal cells.


Soy Isoflavones Genistein COA

ItemsSpecificationResults
AppearanceOff-white or light yellow powderConform
OdorCharacteristicConform
Genistein(HPLC)NLT 98 %98.11%
Mesh Size90% through 80 meshConform
Loss on DryingNMT 5.0 %0.36%
AshNMT 3.0 %0.45%
Heavy MetalNMT 10.0ppmConform
Total Plate CountNMT 1000cfu/gConform
Yeast &MoldNMT 100cfu/gConform
E. ColiNegativeNegative
SalmonellaNegativeNegative


Natural genistein origin and physical and chemical properties

Genistein comes from natural and precious plants, and a small amount exists in dental and legumes. Human intake of Genistein is mainly derived from trace amounts of dietary isoflavones. Genistein is a specific tyrosine protein kinase inhibitor.


Genistein is an isoflavone monomer component extracted from natural plants, which is a trihydroxy compound with an aromatic A-ring


Molecular formula: C15H10O5


Molecular weight: 270.2


Genistein is a rectangular or hexagonal rod-shaped crystal (60% ethanol), dendrite (diethyl ether), melting point: 297~298℃. Soluble in common organic solvents, almost insoluble in water, soluble in dilute bases, and yellow.


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