Views: 0 Author: Site Editor Publish Time: 2022-10-24 Origin: Site
There's a good chance you've tried quercetin without knowing it. Quercetin is a pigment found in many fruits, vegetables and plants. Quercetin belongs to the family of bioflavonoids and is responsible for the bright color and medicinal properties of many plants. You can get quercetin through a balanced diet or as a food supplement. Foods and drinks that contain quercetin include berries, apples, citrus fruits, kale, tomatoes, onions, buckwheat, red wine, and black tea. It can also be found in herbs such as ginkgo biloba and St. John's wort. Quercetin can be taken as a supplement, among other products. It acts as an antioxidant, neutralizing free radicals that cause cell and DNA damage. Known for its antibacterial and anti-inflammatory properties, quercetin can prevent neurological disorders and reduce high blood pressure.
In short, COVID-19 is a disease caused by a coronavirus. Human coronaviruses are common and are often associated with respiratory infections ranging from the common cold to severe infections. SARS-CoV-2, a positive, single-stranded coronavirus caused the outbreak of COVID-19. Transmission occurs primarily through airborne droplets from coughs and sneezes within two meters. Indirect contact through contaminated surfaces is also possible, but will not survive for more than a day on cardboard, several hours on copper, and may be inactivated by soaps or disinfectants. The incubation period for COVID-19, the time from when a person contracts the virus until symptoms appear, lasts 5-6 days, but can be between 2 and 14 days. Latest findings The latest findings suggest that SARS-CoV-2 may remain detectable for 37 days. After entering the human body, the virus begins to replicate. The immune system is not ready to recognize new viruses and fight them effectively.
In addition to anti-inflammatory, anti-mutant, and anti-carcinogenic properties, quercetin is thought to exert antiviral effects and the ability to control the functions of major cellular enzymes. Quercetin is thought to have the potential to work against the novel coronavirus, and here is the mechanism that demonstrates its potential.
To enter cells, CoV binds to a receptor on the surface of the host cell – in the case of the novel coronavirus, angiotensin-converting enzyme 2 (ACE2). Once inside the host cell, the viral RNA attaches to the host's ribosome for translation of the homologous polypeptide. This is accompanied by the protein being broken down into smaller polypeptides or amino acids. This process, called proteolysis, is important for packaging new viral parts. The major protease (3CLpro) and papain-like protease (PLpro) of coronaviruses are involved in the proteolytic process and, therefore, are essential for the virus.
A 2019 study by Korean scientists suggested that quercetin and other flavonoids may inhibit the proteolytic activity of SARS-CoV 3C-like proteases, resulting in antiviral effects.
The coronavirus uses the ACE 2 receptor to enter somatic cells, emptying its RNA content and hijacking it, producing more virus. Therefore, preventing SARS-CoV-2 from binding to the ACE 2 receptor means that the virus cannot enter somatic cells. A computer simulation study shows that quercetin, like other compounds, prevents the new coronavirus from entering cells.
Quercetin acts as a nutrient stimulator of Sirtuin function and inhibits mTOR activity. This means that it challenges viral replication. Since quercetin is poorly absorbed, it is best to start taking it as a supplement long before exposure, so that it has time to build up. In addition, quercetin has a good safety profile and can cause anti-inflammatory effects.
In vitro studies using viral plaque reduction techniques on cell culture monolayers, natural flavonoids such as quercetin have been shown to be effective against herpes simplex virus type 1 (HSV-1), poliovirus type 1, parainfluenza virus Type 3 (Pf-3) and respiratory syncytial virus (RSV) are effective. During the study, quercetin caused a concentration-dependent reduction in infectivity of each virus. In addition, it reduced intracellular replication of each virus.
Other studies have shown that quercetin has antiviral activity against HIV-luc/SARS but very low cytotoxicity. Quercetin has been shown to inhibit influenza infection, including broad-spectrum strains such as H1N1 and H3N2, at half-maximal inhibitory concentrations. Furthermore, using a pseudovirus-based drug screening system, quercetin could inhibit entry of the H5N1 virus. A 2016 study noted that the inhibitory activity elicited by quercetin in the early stages of influenza infection may be a future therapeutic option to create safe, effective and affordable natural products to treat and prevent influenza A virus.
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