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Hyaluronic acid (referred to as HA) is an acidic mucopolysaccharide composed of D-glucuronic acid disaccharide units and N-acetylglucosamine. It is widely found in connective tissues such as eye glass bulbs, human cells, and synovial fluid. important constituents. It is now commonly produced by microbial fermentation and sold in the form of its sodium salt (sodium hyaluronate). The outer layer of the hyaluronic acid molecular structure contains functional groups: hydroxyl, carboxyl, etc. These functional groups act through hydrogen bonds, etc., making it a strong water absorbing agent. As a humectant, hyaluronic acid is widely used in various cosmetics, also known as the fourth-generation cosmetic additive or biomimetic cosmetic additive.
1. Hyaluronic acid is the main component of connective tissues such as interstitial cells, vitreous body, and synovial fluid of the human body. It plays important physiological functions in the body to retain water, maintain extracellular space, regulate osmotic pressure, lubricate, and promote cell repair.
2. As the main component of the intercellular matrix, hyaluronic acid directly participates in the regulation of electrolyte exchanges inside and outside cells, and plays the role of a filter for physical and molecular information. Hyaluronic acid has unique physicochemical properties and physiological functions.
3. It can be used as a viscoelastic agent for ophthalmic intraocular lens implantation surgery, a filler for joint surgery such as osteoarthritis and rheumatoid arthritis, and also used to prevent postoperative adhesion and promote skin wound healing.
4. The compound formed by the reaction of hyaluronic acid and other drugs exerts a sustained release effect on the drug, and can achieve the purpose of directional and timed release.
5. Hyaluronic acid originally exists in the skin, which can help the skin absorb water from the body and the surface of the skin, and can also enhance the skin's long-term water retention capacity. When hyaluronic acid absorbs water, it makes elastic fibers and collagen in a moist environment, so the skin has elasticity.
1. It has been widely used in medicine and is widely used in various ophthalmic surgeries.
2. When used in cosmetics, it can play a unique role in protecting the skin, keeping the skin moist and smooth, delicate and tender, elastic, and has the functions of anti-wrinkle, anti-wrinkle, beauty care and restoring the physiological function of the skin.
Hyaluronic acid (referred to as HA) is an acidic mucopolysaccharide composed of D-glucuronic acid disaccharide units and N-acetylglucosamine. It is widely found in connective tissues such as eye glass bulbs, human cells, and synovial fluid. important constituents. It is now commonly produced by microbial fermentation and sold in the form of its sodium salt (sodium hyaluronate). The outer layer of the hyaluronic acid molecular structure contains functional groups: hydroxyl, carboxyl, etc. These functional groups act through hydrogen bonds, etc., making it a strong water absorbing agent. As a humectant, hyaluronic acid is widely used in various cosmetics, also known as the fourth-generation cosmetic additive or biomimetic cosmetic additive.
1. Hyaluronic acid is the main component of connective tissues such as interstitial cells, vitreous body, and synovial fluid of the human body. It plays important physiological functions in the body to retain water, maintain extracellular space, regulate osmotic pressure, lubricate, and promote cell repair.
2. As the main component of the intercellular matrix, hyaluronic acid directly participates in the regulation of electrolyte exchanges inside and outside cells, and plays the role of a filter for physical and molecular information. Hyaluronic acid has unique physicochemical properties and physiological functions.
3. It can be used as a viscoelastic agent for ophthalmic intraocular lens implantation surgery, a filler for joint surgery such as osteoarthritis and rheumatoid arthritis, and also used to prevent postoperative adhesion and promote skin wound healing.
4. The compound formed by the reaction of hyaluronic acid and other drugs exerts a sustained release effect on the drug, and can achieve the purpose of directional and timed release.
5. Hyaluronic acid originally exists in the skin, which can help the skin absorb water from the body and the surface of the skin, and can also enhance the skin's long-term water retention capacity. When hyaluronic acid absorbs water, it makes elastic fibers and collagen in a moist environment, so the skin has elasticity.
1. It has been widely used in medicine and is widely used in various ophthalmic surgeries.
2. When used in cosmetics, it can play a unique role in protecting the skin, keeping the skin moist and smooth, delicate and tender, elastic, and has the functions of anti-wrinkle, anti-wrinkle, beauty care and restoring the physiological function of the skin.
Items | Standard requirement | Results |
Physical & Chemical Test | ||
Identification | IR Identification or comparable test | Complies |
Appearance | White powder | Complies |
Transparency(in0.1%aq.sol.) | ≥99.0% | 99.9% |
PH | 6.0~7.5 | 6.6 |
Intrinsic viscosity | (0.19~0.28)dL/g | 0.27dL/g |
Molecular weight | (3.0~5.0)KDa | 4.82KDa |
Kinematic viscosity | Actual value | 1.33mm²/s |
Mesh | ≥60 | Complies |
Purity Test | ||
Loss on drying | ≤10.0% | 9.0% |
Residue on ignition | 15.0~20.0% | 18.7% |
Heavy metals | ≤20ppm | <20ppm |
Arsenic | ≤2ppm | <2ppm |
Protein | ≤0.1% | 0.06% |
Assay | ≥93.0% | 96.8% |
Glucuronic acid | ≥45.0% | 46.8% |
Microbiological Purity | ||
Total bacterial count | ≤100CFU/g | <100CFU/g |
Yeasts & mold | ≤10CFU/g | <10CFU/g |
E. coli | Negative | Negative |
Staph | Negative | Negative |
Pseudomonas aeruginosa | Negative | Negative |
Salmonella | Negative | Negative |
Conclusion: Conform with Specification |
Items | Standard requirement | Results |
Physical & Chemical Test | ||
Identification | IR Identification or comparable test | Complies |
Appearance | White powder | Complies |
Transparency(in0.1%aq.sol.) | ≥99.0% | 99.9% |
PH | 6.0~7.5 | 6.6 |
Intrinsic viscosity | (0.19~0.28)dL/g | 0.27dL/g |
Molecular weight | (3.0~5.0)KDa | 4.82KDa |
Kinematic viscosity | Actual value | 1.33mm²/s |
Mesh | ≥60 | Complies |
Purity Test | ||
Loss on drying | ≤10.0% | 9.0% |
Residue on ignition | 15.0~20.0% | 18.7% |
Heavy metals | ≤20ppm | <20ppm |
Arsenic | ≤2ppm | <2ppm |
Protein | ≤0.1% | 0.06% |
Assay | ≥93.0% | 96.8% |
Glucuronic acid | ≥45.0% | 46.8% |
Microbiological Purity | ||
Total bacterial count | ≤100CFU/g | <100CFU/g |
Yeasts & mold | ≤10CFU/g | <10CFU/g |
E. coli | Negative | Negative |
Staph | Negative | Negative |
Pseudomonas aeruginosa | Negative | Negative |
Salmonella | Negative | Negative |
Conclusion: Conform with Specification |